Hero Background

Isoform Oncology

Isoform Oncology is pioneering the development of novel cancer biotherapeutics by exploiting isoform switching and alternative splicing.

We address a critical care gap for refractory patients - those who lack key targets or have developed resistance to blockbuster treatments.

Our Approach

Alternative splicing generates disease-specific protein variations and is often hijacked in cancer, creating unique, actionable targets that remain untapped by conventional therapies.

By identifying and drugging these cancer-specific isoforms, we aim to selectively attack and kill tumor cells, offering new hope for patients who currently have no effective options.

Our programmes are targeting

early onset, BRAFwt, MSS colorectal cancer metastatic triple negative, BRCAwt, PD1 low breast cancer non-muscle invasive, gemcitabine resistant bladder cancer
Cancer is not solved
Patients need more

Our Team

Lee Larcombe

Lee Larcombe

CEO & Co-founder

Computational biologist; PhD in synthetic antigen design for antibody development.

Sarah Morgan

Sarah Morgan

CSO & Co-founder

Translational biologist; PhD in variant splice targets in cancer; MA in healthcare law and ethics.

Emilie Syed

Emilie Syed

Investor Director

Venture builder; PhD in neuroscience.

Isabella Garcia

Isabella Garcia

Discovery Lead

PhD in isoform-specific alternative splicing.

Jurgen Moll

Jurgen Moll

Scientific Advisor

Oncology drug discovery: Boehringer-Ingelheim, Sanofi, Pfizer.

Team member

Mark Bailey;

Venture Partner

Founder, biotech leader and advisor.

Our supporters and partners

Our Mission

We are building therapies for patients that current medicines leave behind.

Everyone deserves precise and effective medicines that work:

On target.    On time.    Every time.