Lee Larcombe
CEO & Co-founder
Computational biologist; PhD in synthetic antigen design for antibody development.
Isoform Oncology is pioneering the development of novel cancer biotherapeutics by exploiting isoform switching and alternative splicing.
We address a critical care gap for refractory patients - those who lack key targets or have developed resistance to blockbuster treatments.
Alternative splicing generates disease-specific protein variations and is often hijacked in cancer, creating unique, actionable targets that remain untapped by conventional therapies.
By identifying and drugging these cancer-specific isoforms, we aim to selectively attack and kill tumor cells, offering new hope for patients who currently have no effective options.
Our programmes are targeting
CEO & Co-founder
Computational biologist; PhD in synthetic antigen design for antibody development.
CSO & Co-founder
Translational biologist; PhD in variant splice targets in cancer; MA in healthcare law and ethics.
Investor Director
Venture builder; PhD in neuroscience.
Discovery Lead
PhD in isoform-specific alternative splicing.
Scientific Advisor
Oncology drug discovery: Boehringer-Ingelheim, Sanofi, Pfizer.
Venture Partner
Founder, biotech leader and advisor.
We are building therapies for patients that current medicines leave behind.
Everyone deserves precise and effective medicines that work:
On target. On time. Every time.